EPFL BioE Talks SERIES "Stem Cell Zoo – Platform to Study Species-Specific Biological Tempo"
Event details
| Date | 12.05.2025 |
| Hour | 12:15 › 13:15 |
| Speaker | Prof. Miki Ebisuya, Physics of Life, TU Dresden (DE) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
WEEKLY EPFL BIOE TALKS SERIES (sandwiches provided)
Abstract:
Different animal species operate at distinct biological tempos. Our group investigates the mechanisms underlying species-specific biological tempo using stem cell-based in vitro models.
So far, we have successfully recaplitulated the segmentation clock—oscillatory gene expression during early development—using pluripotent stem cells from six mammalian species, including human, mouse, marmoset, and rhinoceros. Our findings indicate that these differences arise from variations in the kinetics of the segmentation clock mechanism, including species-specific protein degradation rates and delays in gene expression processes. Moreover, we have shown that several metabolic inhibitions selectively impact these kinetics.
Expanding our exploration of biological tempo, we are now studying species-specific heart rates by deriving cardiac pacemaker cells from our stem cell zoo.
Bio:
Education:
2003–2008: Graduate School of Biostudies, Kyoto University (Dr. Eisuke Nishida lab) – Ph.D.
1999–2003: Faculty of Science, Kyoto University – B.Sc.
Scientific Career:
2023–current
Alexander von Humboldt Professor, Chair of Cell and Tissue Control, Cluster of Excellence Physics of Life, TU Dresden, Germany
2018–2025
Group Leader at EMBL Barcelona, Spain (2023-2025 Visiting Group Leader)
2013–2019
Unit Leader, RIKEN, Japan
2009–2013
Group Leader, Career-Path Promotion Unit, Kyoto University, Japan
2008
PhD, Kyoto University, Japan.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students planning to attend this talk, who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
Abstract:
Different animal species operate at distinct biological tempos. Our group investigates the mechanisms underlying species-specific biological tempo using stem cell-based in vitro models.
So far, we have successfully recaplitulated the segmentation clock—oscillatory gene expression during early development—using pluripotent stem cells from six mammalian species, including human, mouse, marmoset, and rhinoceros. Our findings indicate that these differences arise from variations in the kinetics of the segmentation clock mechanism, including species-specific protein degradation rates and delays in gene expression processes. Moreover, we have shown that several metabolic inhibitions selectively impact these kinetics.
Expanding our exploration of biological tempo, we are now studying species-specific heart rates by deriving cardiac pacemaker cells from our stem cell zoo.
Bio:
Education:
2003–2008: Graduate School of Biostudies, Kyoto University (Dr. Eisuke Nishida lab) – Ph.D.
1999–2003: Faculty of Science, Kyoto University – B.Sc.
Scientific Career:
2023–current
Alexander von Humboldt Professor, Chair of Cell and Tissue Control, Cluster of Excellence Physics of Life, TU Dresden, Germany
2018–2025
Group Leader at EMBL Barcelona, Spain (2023-2025 Visiting Group Leader)
2013–2019
Unit Leader, RIKEN, Japan
2009–2013
Group Leader, Career-Path Promotion Unit, Kyoto University, Japan
2008
PhD, Kyoto University, Japan.
Zoom link (with one-time registration for the whole series) for attending remotely: https://go.epfl.ch/EPFLBioETalks
Instructions for 1st-year Ph.D. students planning to attend this talk, who are under EDBB’s mandatory seminar attendance rule:
IN CASE you cannot attend in-person in the room, please make sure to
- send D. Reinhard a note well ahead of time (ideally before seminar day), informing that you plan to attend the talk online, and, during seminar:
- be signed in on Zoom with a recognizable user name (not any alias making it difficult or impossible to identify you).
Practical information
- Informed public
- Registration required
Organizer
- Prof. David Suter, Institute of Bioengineering
Contact
- Institute of Bioengineering (IBI), Dietrich REINHARD